||Año y revista publicación
||Persona que lo propone
chikungunya. Manifestaciones reumáticas de una infección
emergente en Europa
||2014 Reumatología Clínica
||Una severa reacción inmunitaria de defensa con
incremento de citocinas proinflamatorias es la responsable
de la inflamación articular. El tratamiento es sintomático. No
disponemos de terapia antiviral
específica ni vacuna preventiva. Por ello, debemos profundizar en el
estudio de la inmunopatogénesis,
con el fin encontrar dianas terapéuticas más apropiadas.
||Luis Alejandro Satizábal Bernal
Management of Post-Chikungunya
Rheumatic Disorders: A Retrospective Study of 159 Cases in Reunion
Island from 2006-2012
||2015 PLOS Neglected Tropical Diseases
||We conducted a 6-year case series retrospective study
in Reunion Island of patients referred
to a rheumatologist due to continuous rheumatic or musculoskeletal
pains that persisted
following CHIK infection. These various disorders were documented in
terms of their
clinical and therapeutic courses. Post-CHIK de novo chronic
(CIRs) were identified according to validated criteria.
|Acute Chikungunya and persistent musculoskeletal pain
following the 2006 Indian epidemic: a 2-year prospective rural community study
||Epidemiol. Infect. (2012),
||Chikungunya virus (CHIKV) data from population studies are sparse. During the 2006 epidemic,
509 clinical cases (43% attack rate) were identified in a village survey (West India) ; laboratory
investigations demonstrated normal blood cell counts, elevated acute-phase reactants [erythrocyte
sedimentation rate, C-reactive protein and interleukin-6 (IL-6)] and excluded malaria and dengue.
Acute CHIKV was characterized by high fever, severe peripheral polyarthralgias, axial myalgias
and intense fatigue in over 90% of cases; skin rash (34%) and headache (19%) were uncommon.
There were 49% and 62% of survey cases seropositive for IgM (rapid assay) and IgG
(immunofluorescence) anti-CHIKV antibodies, respectively. Sixty-five percent of cases recovered
within 4 weeks. None of the cases died. Of the population, 4.1% and 1.6% suffered from
persistent rheumatic pains, predominantly non-specific, at 1 and 2 years, respectively. Chronic
inflammatory arthritis was uncommon (0.3% at 1 year) although serum IL-6 often remained
elevated in chronic cases. A larger population study is required to describe post-CHIKV
rheumatism and its prognosis.
||Diana Isabel Mora
|Identification of initial severity determinants to
predict arthritis after chikungunya infection in a
cohort of French gendarmes
||Musculoskeletal Disorders 2014
||The objective was to identify severity characteristics of initial chikungunya infection (CHIKV) stages
associated with post-CHIKV arthritis and arthralgia.
|Predictors of Chikungunya rheumatism: a
prognostic survey ancillary to the TELECHIK
||Arthritis Research & Therapy 2013
||Long-lasting relapsing or lingering rheumatic musculoskeletal pain (RMSP) is the hallmark of
Chikungunya virus (CHIKV) rheumatism (CHIK-R). Little is known on their prognostic factors. The aim of this
prognostic study was to search the determinants of lingering or relapsing RMSP indicative of CHIK-R.
|Arthritis after infection with Chikungunya virus
||Best Practice & Research Clinical
||Knowledge of the geographical
epidemiology of CHIKV infection is crucial for better control of the
disease. Thus, recent outbreaks have led to several studies, which
have highlighted the need for a better understanding of the clinical
features of Chikungunya (CHIK) and beginning knowledge of the
pathophysiogenesis, which can lead to further research.
|Chronic Joint Disease Caused by Persistent Chikungunya Virus
Infection Is Controlled by the Adaptive Immune Response
||Journal of Virology 2013
||These findings suggest that
chronic musculoskeletal tissue pathology is caused by persistent CHIKV infection and controlled by adaptive immune responses.
Our results have significant implications for the development of strategies to mitigate the disease burden associated
with CHIKV infection in humans.
|Prevalence of and risk factors for chronic arthralgia
and rheumatoid-like polyarthritis more than 2 years
after infection with chikungunya virus
||Postgrad Med J 2013
||There is increasing evidence that it
also causes longer-term rheumatic symptoms. In a
circumscribed part of Mauritius where infectivity was
high, a cohort of inhabitants was surveyed with the
objectives of assessing the prevalence of and risk factors
for chronic musculoskeletal symptoms and for a
rheumatoid arthritis-like condition at 27.5 months after
|Chronic inflammatory arthritis with persisting bony erosions in
patients following chikungunya infection
||Indian J Med Res 2014
||The original study group cohort consisted of 203
patients with chikungunya fever identified during an
outbreak in Dakshina Kannada district of Karnataka
State, India, in 2008. The presence of CHIKV infection
in these patients was confirmed by the presence of anti-
CHIKV IgM antibodies. These patients were followed
up for a period of 10 months. Ninety four of these 203
patients continued to have arthritic symptoms at the
end of 10 months.
||Esta en formato comprimido
||Enviados varios Dr Medina.